Clinical Trial Intelligence Orchestration

Every clinical
trial delay has a
human cost.

Samaras is the orchestration layer that connects fragmented clinical trial operations and systems — applying contextual protocol intelligence across the full trial lifecycle so your teams can focus on patients, not process.

10x
Enrollment
Throughput
6x
Visit
Throughput
63%
Reduction in
Cost at High Volume
Increase Velocity.
Volume. Rigor.
Become the next-gen clinical trial site — powered by Samaras.

What happens when patients and clinical trial teams  are supported throughout the lifecycle of a clinical trial?

Founder Vision

Click Here to see our Founders message

PROTOCOL INTELLIGENCE

PATIENT RECRUITMENT

MEDICAL INTAKE

SITE ENABLEMENT

CLINICAL REASONING

PROTOCOL INTELLIGENCE

PATIENT RECRUITMENT

MEDICAL INTAKE

SITE ENABLEMENT

CLINICAL REASONING

PROTOCOL INTELLIGENCE

PATIENT RECRUITMENT

MEDICAL INTAKE

SITE ENABLEMENT

CLINICAL REASONING

Socratic Teaching

Adaptive Learning

Real-Time Feedback

Competency Mapping

Socratic Teaching

Adaptive Learning

Real-Time Feedback

Competency Mapping

Harnessing the power of site intelligence to accelerate clinical trials

Samaras is solving critical systemic issues in the clinical trial execution space — one bottleneck at a time.

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Milestone #1

The broken
pre-screening model.

The data the industry has quietly accepted as normal.

80%
Of trials miss enrollment targets
Recruitment failure is the leading cause of trial delays and terminations — costing sponsors months and millions per day.

Tufts Center for the Study of Drug Development(Tufts CSDD)
17.3%
Of pre-screened patients ever reach formal screening
More than 4 in 5 patients are eliminated before formal screening even begins —their data uncaptured, their potential eligibility for other trials lost entirely.

Tufts Center for the Study of Drug Development(Tufts CSDD)
$1.89B
Spent on patient recruitment annually in the US alone
Recruitment is the single largest cost driver in clinical trials — consuming 40% of the total trial budget. Most of it is waste generated by a broken model.

Clinical Leader — Considerations for Improving Patient Recruitment into Clinical Trials
0
Longitudinal patient intelligence retained
Under the current model, a patient who doesn't qualify today is gone forever even if next month's protocol would have been a perfect match.

PMC — Pre-Screening in Clinical Trials: Incentives, Behaviours, Consequences, 2025

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Samaras is building the system that changes it.

From fragmented
to orchestrated.

We didn't build another point solution. Samaras is a connective intelligence layer that wraps your entire clinical operation — from first patient contact to trial close-out — in a single, coherent system.

01
INTAKE
Capture patients protocol-agnostically
MIA, our Medical Intake Agent, is clinically grounded and collects a comprehensive medical history curated for clinical trials, creating space for each patient interested in clinical trial
participation.
02
INTELLIGENCE
Match across all protocols simultaneously
The Protocol Intelligence Agent (PIA) evaluates each patient against your entire active portfolio — finding matches human screeners lack the time to catch.
03
THE FUTURE
From finding patients for trials — to building trials for patients.
The longitudinal patient data captured by MIA doesn't just solve today's recruitment problem. It becomes the foundation for a fundamental industry shift — where sponsors design protocols around patient populations that actually exist, not the other way around.

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Milestone #2

The shrinking
site workforce.

The investigator pool is contracting. Staff are burning out. We are losing institutional knowledge faster than it can be replaced — and trials keep multiplying, in number and complexity.

10%
Shrinking Investigator Pool
Decline in clinical trial investigators globally between 2017-2024 — from 128,303 to 116,948.

GlobalData / Clinical Trials Arena, 2025
28%
Decline in Coordinators
Drop in site coordinators in the same peroid — from 56,036 to just 40,472.

GlobalData / Clinical Trials Arena, 2025
60%
Loss of Institutional Knowledge
Higher resignation rate among experienced clinical research professionals (5–10 yr tenure) vs. 2020.

PMC — Now Is the Time to Fix the Clinical Research Workforce Crisis, 2023
"1 & done"
Administrative Burden Overload
Many new investigators conduct a single trial and never return — leaving sites perpetually rebuilding from zero.

ACRP — Is the Clinical Trial Workforce Prepared
for the Future?

And the trials keep multiplying

Fewer experts.
More trials.
Greater complexity.

The number of registered clinical trials has grown from roughly 2,000 in 2000 to over 515,000 globally by 2024. Since 2005, endpoints have risen 214%, procedures by 139% and data points collected by 600%. Sites are being asked to absorb more complexity than ever — with fewer people to carry it.

Sources: Statista / ClinicalTrials.gov, 2024 — IQVIA, Assessing Protocol Complexity and its Impact on Trial Outcomes, 2026

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Samaras is building the system that changes it.

Three pillars that turn any site into a trial-ready operation.

Regardless of experience level, team size, or portfolio complexity — Samaras builds the training infrastructure that lets sites do more with the teams they have, and rapidly upskill the ones they're bringing in.

Watch — Innovation Network

Patient Negative One

Founder Kaye Doiron at the Innovation Network Gathering — on why clinical trials fail patients before they ever begin, and the insight that sparked Samaras.

01
SITE ENABLEMENT
Scale and upskill the workforce — fast.
Samaras delivers clinically grounded, simulation-based training that adapts to each learner — building proficiency through agentic, interactive case studies with real-time mastery feedback. We help medical professionals offer clinical trials as a care option, not a specialty reserved for the already experienced.
02
PROTOCOL SPECIFIC TRAINING
Trial-ready teams before day one.
Powered by PIA's deep protocol intelligence, Samaras generates protocol-specific simulation training environments where teams demonstrate proficiency before a trial begins. We build workflow process maps and keep sites aligned from activation through close-out.
03
PATIENT EDUCATION
Standardize and automate the patient experience.
Samaras delivers clinically grounded, standardized information and automates protocol-specific patient education — ensuring every patient receives consistent, accurate information about the trial they're entering, in language they can understand, at every site.

Milestone #3

Site sustainability at risk.

Running a clinical trial site has never been harder to sustain financially. The cost of activation is rising. Sponsor timelines are compressing. Sites are absorbing more operational burden per trial than ever — with fewer resources to carry it.

$800K
Cost per day of clinical trial delay
Pressure that flows directly onto sites through tightening timelines and compressed budgets.

Tufts Center for the Study of Drug Development
(CSDD)

35–45%
Of protocols require at least one major amendment
Each costing sites unbudgeted time,
retraining, and workflow disruption — with no compensation.

GlobalData / Clinical Trials Arena, 2025
22%
Higher dropout rate at high-burden sites
Directly threatening per-patient revenue and sponsor confidence in the site's ability to deliver.

IQVIA, Assessing Protocol Complexity and its
Impact on Trial Outcomes, 2026
40%
Of trial budgets consumed by recruitment alone
The single largest cost driver — and the one Samaras directly transforms through intelligent, protocol-agnostic intake. By reducing recruitment costs, sites can redirect budget into operations staff and infrastructure that supports greater throughput.

Clinical Leader — Considerations for Improving Patient Recruitment into Clinical Trials

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Samaras is building the system that changes it.

Samaras is a workforce amplifier.

Not by asking staff to move faster — but by decentralizing data collection across every patient visit, standardizing quality at scale, and returning time that has been lost to administrative friction. Sites grow their patient databases and 10× their throughput without adding headcount, sacrificing quality, or compromising safety.

01
10× Site Database Growth
Every patient is a longitudinal asset.
Samaras captures complete, structured patient data in a protocol-agnostic fashion — every interested patient, every visit, every interaction. No lead is lost. No data is siloed. Sites build a living, growing patient intelligence database that compounds in value with every trial cycle, continuously matched across current and future studies.
02
10× Enrollment · 6× Visit Throughput
Decentralize collection.
Centralize intelligence.
By moving data collection out of the clinic and directly to patients at home — through SARA's protocol- aligned visit conversations and MIA's intake engine — sites process up to 10× more enrollment candidates and 6× more study visits without expanding their physical footprint or staff roster. Patients reach sites 99% faster. Staff time is reduced by 63%.
03
Quality · Safety · Compliance
More volume. No compromise on rigor.
Every Samaras interaction is clinically grounded, protocol-intelligent, ALCOA-C++ aligned, and ICH-GCP compliant. Standardized data collection across every patient and every visit eliminates the variability that comes with manual workflows — so as volume scales, quality scales with it. Sites don't choose between growth and rigor. Samaras makes both possible simultaneously.

The Samaras Platform

An agentic market-place built to grow with you.

Every site is different. Every trial is different. Samaras is designed around that reality — a central orchestration  layer that coordinates purpose-built agents behind the scenes, so your team experiences one seamless system, not a stack of disconnected tools. Start with what you need. Add as you grow.

PIA

Protocol Intelligence Agent
FRAGMENTS → STRUCTURED INTELLIGENCE
B UP TO 1,000 PATIENTS · PER DAY · PER SITE
CLINICIAN-GRADE INTAKE · PATIENT-FIRST PACE
Coming Soon
SARA STUDY AMBASSADOR & RESEARCH ASSISTANT
PIA supports teams with clinical reasoning and protocol intelligence throughout the entire life-cycle of a clinical trial. PIA takes fragmented systems and operational instructions and converts them into structured, executable intelligence.

01

Beautiful hills & stuff

02

Some kind of cave

Ehm, a cool house

03

Site_Enablement

Site_Training

Simulations

Patient_Education

Patient_Recruitment

Patient_Engagement

Protocol_Intelligence

Clinical_Reasoning

Pharmacovigilance

Process_Mapping

KPI_Tracking

Clinical_Reasoning

Pharmacovigilance

Safety

Site_Enablement

Simulations

Samaras

is an agentic orchestration layer that connects fragmented clinical trial systems and applies contextual clinical and protocol intelligence across end-to-end trial workflows, informed by over 20 years of operational data.

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The greatest challenge in clinical trials isn't science — it's fragmented systems and time lost to unnecessary complexity. Samaras exists to give that time back.

Kaye Doiron

CEO & Founder, Samaras — A ThinkHat Venture Studio Company

Built from the inside out.

20+ yrs
Hands-on experience running clinical trial research sites — the founding insight came from living the operational pain firsthand.
2024
Samaras founded within ThinkHat Venture Studio — combining site intelligence with AI orchestration to solve the problem at its root.
Now
Active agents deployed at Beta Sites — integrations with major CTMS providers RealTime, CRIO, and Clinical Conductor, with deep embedded integration with SiteCentric.
Vision
Phase 2 — helping pharma design protocols around patient populations that already exist. Patients as longitudinal assets, not disposable leads. Samaras becomes the standard operational layer for clinical trial execution

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The ecosystem

Connected intelligence, end to end.

Samaras is the orchestration layer connecting a purpose-built stack of clinical intelligence tools into a single coherent continuum.

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Ready to give your
team their time
back?

Whether you're a site director, sponsor, or CRO — let's talk about what
Samaras can do for your trials.

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